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The Nigeria Centre for Disease Control and Prevention (NCDC) has reported that the death toll from Lassa fever has continued to climb, reaching 53 fatalities nationwide.
In its latest situation report via its official website, the NCDC said 76 confirmed cases were recorded between January 20 and 26, marking a slight decrease from the 71 cases reported in the previous week.
The centre, however, reported a decline in confirmed cases for the fourth epidemiological week of 2025.
It said the cumulative data for 2025 showed a total of 290 confirmed cases and 1,171 suspected cases across 10 states, with a case fatality rate (CFR) of 18.3 percent.
It noted that this represented a marginal improvement compared to the 18.6 percent CFR recorded during the same period in 2024.
The NCDC report highlighted that 75 percent of all confirmed cases were concentrated in Ondo, Edo, and Bauchi states. Ondo State led with 37 percent of the total cases, followed by Edo with 21 percent and Bauchi with 17 percent.
“The disease has affected 54 local government areas across the country, with the predominant age group being from 21 to 30 years.
“The male-to-female ratio among the confirmed cases is nearly equal at 1:0.9,” it said.
Despite the overall decline in new cases, the agency said that it remained concerned about the rising death toll.
It attributed the death toll to late presentation of cases, poor health-seeking behaviour due to the high cost of treatment and inadequate environmental sanitation in high-burden communities.
In response to the outbreak, the NCDC said that it had activated a multi-sectoral Incident Management System (IMS) to coordinate control efforts at all levels.
“Key activities include deploying National Rapid Response Teams, conducting risk communication and community engagement in affected areas, and enhancing surveillance and contact tracing efforts,” it noted.
It said healthcare workers had also been trained in case management in high-burden states like Bauchi, Ebonyi, and Benue, with plans to expand the training to Plateau and Taraba states.
The agency said that Lassa fever treatment centres across the country had been equipped with essential response commodities, including personal protective equipment (PPE), Ribavirin and infection prevention materials.
However, it outlined significant challenges, including poor awareness in high-risk communities and delayed case reporting, which continues to hinder effective outbreak control.
The NCDC urged Nigerians to remain vigilant and adopt preventive measures, like maintaining proper hygiene, storing food properly to avoid contamination by rodents and seeking medical attention promptly if symptoms occurred.
The agency said it had also disseminated public health advisories and continues to provide offsite support to state health authorities to strengthen response efforts.
Lassa fever is endemic in Nigeria, with outbreaks occurring almost yearly. It was first identified in 1969 in Lassa, Borno State.
Symptoms range from mild fever and joint pain to severe bleeding from the nose, mouth and gastrointestinal tract.
The disease is fatal in about 20 percent of cases, particularly when treatment is delayed.
Across West Africa, hundreds of thousands are infected annually, experiencing symptoms such as fever, vomiting and in severe cases, bleeding.
One of the most troubling complications is hearing loss, which affects about 25 percent of survivors.
The estimated fatality rate is one percent, but during outbreaks, mortality can rise significantly, particularly among pregnant women and healthcare workers.
Despite its significant health impact, Lassa fever remains one of the most neglected diseases, with limited resources allocated to its prevention and treatment.
Currently, no licensed vaccines exist, although around 20 candidates are in development with the most advanced in Phase II clinical trials.
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