Albeit of Kwara descent, Salami was born on 9 May 1953 in Lagos State where he had both primary and secondary education.
He began his acting career in 1964 with a group called Young Concert Party, under the leadership of Ojo Ladipo, popularly known as Baba Mero. After a few years, the group changed its name to Ojo Ladipo Theatre Group, and later metamorphosed into Awada Kerikeri Theatre Group.Following the demise of Ojo Ladipo in 1978, Salami took the mantle of leadership of the group, which brought him into the limelight.
He featured in the first Yoruba film, Ajani Ogun, in which the late Adeyemi Afolayan, the father of Kunle Afolayan and Gabriel Afolayan, plays the lead role.
He also featured in a movie titled Kadara by Adeyemi Afolayan (Ade love). He later featured in the popular Nigerian comedy series Comedy half hour with the stage name Oga Bello.
He produced his first movie, Ogun Ajaye, in 1985, from the stable of Awada Kerikeri.
Since 1985, he has produced, directed and featured in several Yoruba movies.
He was a pioneer member of the Association of Nigerian Theatre Arts Practitioners, and also served as president of the association.